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From each included study, we extracted detailed information on the type and source of the bioactive compound, targeted cancer types, experimental models used ( in vitro, in vivo , or clinical), elucidated anticancer mechanisms, and any reported clinical efficacy or safety outcomes

478 Another meta-analysis included three studies involving 226,804 patients with lower extremity peripheral artery disease, a condition linked to increased risk of thrombotic events

Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development

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While studied primarily for cognitive enhancement and stroke recovery, its BDNF-boosting properties have direct relevance to peripheral nerve maintenance and repair